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Bioorg Med Chem Lett. 2011 Jun 15;21(12):3774-9. doi: 10.1016/j.bmcl.2011.04.053. Epub 2011 Apr 20.

Optimization of triazoles as novel and potent nonphlorizin SGLT2 inhibitors.

Author information

1
Amgen Inc., South San Francisco, CA 94080, USA. xdu@amgen.com

Abstract

Previous efforts have led to the identification of a potent, selective, and nonphlorizin based SGLT2 inhibitor 1. This Letter describes efforts to further optimize the potency, microsomal stability, solubility and pharmacokinetic properties of this series of SGLT2 inhibitors. From these efforts, compounds 28 and 32 have improved solubility and pharmacokinetic properties compared to compound 1.

PMID:
21565497
DOI:
10.1016/j.bmcl.2011.04.053
[Indexed for MEDLINE]

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