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Curr Opin Cell Biol. 2011 Aug;23(4):427-34. doi: 10.1016/j.ceb.2011.04.009. Epub 2011 May 10.

Mitochondrial division: molecular machinery and physiological functions.

Author information

1
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Mitochondrial division has emerged as a key mechanism for this essential organelle to maintain its structural integrity, intracellular distribution, and functional competence. An evolutionarily conserved dynamin-related GTPase, Dnm1p/Drp1, interacts with other proteins to form the core machinery involved in mitochondrial division. We summarize recent progress in understanding how the division machinery assembles onto mitochondria and how mitochondrial division contributes to cellular physiology and human diseases.

PMID:
21565481
PMCID:
PMC3379813
DOI:
10.1016/j.ceb.2011.04.009
[Indexed for MEDLINE]
Free PMC Article

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