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Cell Calcium. 2011 May;49(5):290-5. doi: 10.1016/j.ceca.2011.04.003. Epub 2011 May 11.

Biological functions and transcriptional targets of CaRF in neurons.

Author information

1
Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, NC 27710, USA. west@neuro.duke.edu

Abstract

Calcium-response factor (CaRF) is a unique DNA-binding protein first recognized as a transcription factor for its role in modulating transcription of the gene encoding Brain-Derived Neurotrophic Factor (BDNF) in neurons. Here I review evidence for the biological functions and transcriptional targets of CaRF in the brain and discuss potential mechanisms by which calcium-activated signaling pathways may modulate CaRF-dependent transcription. These data paint an emerging picture of CaRF as a regulatory nexus for signaling pathways that control aspects of synaptic development and neuronal function.

PMID:
21565403
PMCID:
PMC3114298
DOI:
10.1016/j.ceca.2011.04.003
[Indexed for MEDLINE]
Free PMC Article

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