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Biochem Biophys Res Commun. 2011 May 27;409(1):96-102. doi: 10.1016/j.bbrc.2011.04.116. Epub 2011 May 1.

ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.

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Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.


The atypical Rho GTPase Wrch-1 has been proposed roles in cell migration, focal adhesion dissolution, stress fibre break down and tight junction heterogeneity. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. ARHGAP30 is related to the Cdc42- and Rac1-specific RhoGAP CdGAP, which was likewise found to bind Wrch-1. In contrast to CdGAP, ARHGAP30 serves as a Rac1- and RhoA-specific RhoGAP. Ectopic expression of ARHGAP30 results in membrane blebbing and dissolution of stress-fibres and focal adhesions. Our data suggest roles for ARHGAP30 and CdGAP in regulation of cell adhesion downstream of Wrch-1.

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