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J Paediatr Child Health. 2012 Mar;48(3):E136-9. doi: 10.1111/j.1440-1754.2011.02083.x. Epub 2011 May 12.

Sterile abscess formation associated with depot leuprorelin acetate therapy for central precocious puberty.

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Department of Endocrinology, Princess Margaret Hospital for Children, Subiaco, Western Australia, Australia.


We describe a case of an 8 year old girl with central precocious puberty. She was commenced on 3 monthly intramuscular depot Leuprorelin acetate therapy, as a result of which she developed sterile abscesses. She was converted to daily subcutaneous Leuprorelin acetate therapy with no recurrence of the abscesses. The possible mechanisms for this reaction are described in the article.

[Indexed for MEDLINE]

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