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Nanoscale. 2011 Jun;3(6):2461-4. doi: 10.1039/c1nr10172b. Epub 2011 May 12.

Differential nano-bio interactions and toxicity effects of pristine versus functionalized graphene.

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1
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Cochin, 682 041, Kerala, India.

Abstract

We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.

PMID:
21562671
DOI:
10.1039/c1nr10172b
[Indexed for MEDLINE]
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