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J Clin Microbiol. 2011 Jul;49(7):2688-90. doi: 10.1128/JCM.00659-11. Epub 2011 May 11.

Isolation of Mycobacterium tuberculosis strains with a silent mutation in rpoB leading to potential misassignment of resistance category.

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1
Servicio de Microbiología y Enfermedades Infecciosas, Hospital Gregorio Marañón, Madrid, Spain.

Abstract

Our study provides an alert regarding the transmission of rifampin-susceptible strains of Mycobacterium tuberculosis with a silent substitution in codon 514 of rpoB. Among 1,450 cases, we identified 12 isolates sharing this mutation and related restriction fragment length polymorphism (RFLP) types. The mutation impaired hybridization with the wild-type probes in three independent commercial assays, which could lead to misassignment of resistance.

PMID:
21562104
PMCID:
PMC3147855
DOI:
10.1128/JCM.00659-11
[Indexed for MEDLINE]
Free PMC Article
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