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Eur J Cell Biol. 2011 Nov;90(11):891-6. doi: 10.1016/j.ejcb.2011.03.001. Epub 2011 May 10.

Integrin-mediated uptake of fibronectin-binding bacteria.

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1
Lehrstuhl Zellbiologie, Universität Konstanz, Germany.

Abstract

Invasion of mammalian cells via cell adhesion molecules of the integrin family is a common theme in bacterial pathogenesis. Whereas some microorganisms directly bind to integrins, other pathogens such as Staphylococcus aureus indirectly engage these receptors via fibronectin-binding proteins (FnBPs). In this review, we summarize the structure-function relationship of FnBPs and the current view of the role of these proteins during pathogenesis in vivo. A major focus will be on recent findings on the role of cholesterol- and sphingolipid-rich membrane microdomains for integrin-initiated uptake of fibronectin-binding bacteria and the surprising inhibitory function of caveolin-1 in this process. The detailed mechanistic understanding of host cell invasion by fibronectin-binding S. aureus can not only serve as a paradigm for other fibronectin-binding pathogenic bacteria, but might also reveal the physiological regulation of endocytosis of ligand-occupied integrins.

PMID:
21561684
DOI:
10.1016/j.ejcb.2011.03.001
[Indexed for MEDLINE]
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