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Dtsch Med Wochenschr. 2011 May;136(20):1057-9. doi: 10.1055/s-0031-1275842. Epub 2011 May 10.

[Hepatitis A - combined prolonged biphasic and cholestatic course of disease].

[Article in German]

Author information

1
Medizinische Klinik und Poliklinik II, Klinikum Großhadern, Ludwig-Maximilians-Universität München. Laura.Schmidt@med.uni-muenchen.de

Abstract

HISTORY AND ADMISSION FINDINGS:

One month after a first manifestation of a hepatitis A infection and transaminases had become normal, a 44-year-old woman again became jaundiced with accompanied by weakness, nausea and nocturnal sweating.

INVESTIGATIONS:

Laboratory tests again showed features of hepatitis with decreased synthetic liver function and hyperbilirubinemia, changes which persisted for 12 weeks. Serological and virological studies revealed a positive test for anti-hepatitis A virus (HAV) IgM and HAV-RNA was detected in the stool.

DIAGNOSIS, TREATMENT AND COURSE:

These tests demonstrated two rare features of hepatitis A, namely a prolonged biphasic course combined with cholestasis form. In addition a hemolytic anaemia developed.

CONCLUSION:

The severity of a relapse of hepatitis A varies: in this case it was more severe than the initial manifestation. The reasons for the different courses of hepatitis A infection remain unclear.

PMID:
21560106
DOI:
10.1055/s-0031-1275842
[Indexed for MEDLINE]

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