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Int J Oncol. 1994 Dec;5(6):1447-53.

Clinical and immunological effects of a synthetic Beta-human chorionic-gonadotropin vaccine.

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1
OHIO STATE UNIV,CTR COMPREHENS CANC,ARTHUR G JAMES CANC HOSP & RES INST,COLUMBUS,OH 43210.

Abstract

We treated 23 patients with non-trophoblastic cancers with escalating doses of a synthetic vaccine consisting of the carboxy-terminal peptide of beta human chorionic gonadotropin conjugated to diphtheria toroid (CTP37), a muramyl dipeptide as an adjuvant, and squalene/mannide monooleate as a vehicle. Toxicity consisted of pain and sterile abscess formation at the injection site and of constitutional symptoms. Diphtheria toxoid hypersensitivity developed in one patient. Immunizations elicited anti-beta hCG IgG antibody which persisted for more than 10 months. Disappearance of circulating hCG present pre-immunization and tumor regressions were observed. Active specific immunotherapy with CTP37 vaccine is well-tolerated and has biological activity in patients with cancer.

PMID:
21559734
DOI:
10.3892/ijo.5.6.1447

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