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Int J Oncol. 1994 Oct;5(4):781-6.

Release of epidermal growth-factor transforming growth-factor-alpha by ovarian-tumors in-vitro.

Author information

1
UMEA UNIV,DEPT GYNAECOL ONCOL,UMEA,SWEDEN. UMEA UNIV,DEPT OBSTET & GYNAECOL,UMEA,SWEDEN. UMEA UNIV,DEPT PHYSIOL,S-90187 UMEA,SWEDEN. UMEA UNIV,DEPT PATHOL,S-90187 UMEA,SWEDEN. KAROLINSKA INST,DEPT MED RADIAT BIOL,STOCKHOLM,SWEDEN.

Abstract

EGF-like activity was measured in media from 3-hour incubations of ovarian tissue from 27 patients with normal postmenopausal ovaries, malignant or benign epithelial tumours. EGF-like activity in the medium was measured using a radioreceptor assay. Malignant tumour tissue released significantly more EGF/TGF-alpha than benign tissues and aneuploid carcinomas more than diploid carcinomas. In spite of varying amounts of tumour cells there was a strong correlation in EGF/TCF-alpha release from the different tissue samples of each patient suggesting paracrine rather than autocrine regulation. The level of EGF-like activity may be a feature of the patient rather than of the tumour cells.

PMID:
21559642
DOI:
10.3892/ijo.5.4.781

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