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Int J Radiat Biol. 2011 Sep;87(9):993-9. doi: 10.3109/09553002.2011.574779. Epub 2011 May 11.

Induction of adaptive response in human blood lymphocytes exposed to 900 MHz radiofrequency fields: influence of cell cycle.

Author information

1
Interuniversity Centre for Interaction Between Electromagnetic Fields and Biosystems at CNR-Institute for Electromagnetic Sensing of Environment, Naples, Italy.

Abstract

PURPOSE:

To investigate the influence of cell cycle on the adaptive response (AR) induced by the exposure of human blood lymphocytes to radiofrequency fields (RF).

MATERIALS AND METHODS:

Human peripheral blood lymphocytes in G(0)-, G(1)- or S-phase of the cell cycle were exposed for 20 hours to an adaptive dose (AD) of 900 MHz RF at an average specific absorption rate of 1.25 W/kg and then treated with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Un-exposed and sham-exposed controls as well as cells treated with MMC alone were included in the study. The incidence of micronuclei (MN) was evaluated to determine the induction of AR.

RESULTS:

The results indicated that the cells which were exposed to AD of RF in G(0)- and G(1)-phase of the cell cycle did not exhibit AR while such a response was observed when the cells were exposed to AD of RF in S-phase of the cell cycle.

CONCLUSIONS:

These results confirmed the observations reported in our previous investigation where AR was observed in human blood lymphocytes exposed to AD of RF in S-phase of the cell cycle and further suggested that the timing of AD exposure of RF is important to elicit AR.

PMID:
21557704
DOI:
10.3109/09553002.2011.574779
[Indexed for MEDLINE]

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