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Dev Neurobiol. 2011 Jun;71(6):403-18. doi: 10.1002/dneu.20818.

Hooks and comets: The story of microtubule polarity orientation in the neuron.

Author information

1
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA. pbaas@drexelmed.edu

Abstract

It is widely believed that signature patterns of microtubule polarity orientation within axons and dendrites underlie compositional and morphological differences that distinguish these neuronal processes from one another. Axons of vertebrate neurons display uniformly plus-end-distal microtubules, whereas their dendrites display non-uniformly oriented microtubules. Recent studies on insect neurons suggest that it is the minus-end-distal microtubules that are the critical feature of the dendritic microtubule array, whether or not they are accompanied by plus-end-distal microtubules. Discussed in this article are the history of these findings, their implications for the regulation of neuronal polarity across the animal kingdom, and potential mechanisms by which neurons establish the distinct microtubule polarity patterns that define axons and dendrites.

PMID:
21557497
PMCID:
PMC3151545
DOI:
10.1002/dneu.20818
[Indexed for MEDLINE]
Free PMC Article

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