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Subcell Biochem. 2011;52:223-59. doi: 10.1007/978-90-481-9069-0_11.

Interactions of transcription factors with chromatin.

Author information

1
Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada, M5S 3E1, hvbakel@gmail.com.

Abstract

Sequence-specific transcription factors (TFs) play a central role in regulating transcription initiation by directing the recruitment and activity of the general transcription machinery and accessory factors. It is now well established that many of the effects exerted by TFs in eukaryotes are mediated through interactions with a host of coregulators that modify the chromatin state, resulting in a more open (in case of activation) or closed conformation (in case of repression). The relationship between TFs and chromatin is a two-way street, however, as chromatin can in turn influence the recognition and binding of target sequences by TFs. The aim of this chapter is to highlight how this dynamic interplay between TF-directed remodelling of chromatin and chromatin-adjusted targeting of TF binding determines where and how transcription is initiated, and to what degree it is productive.

PMID:
21557086
DOI:
10.1007/978-90-481-9069-0_11
[Indexed for MEDLINE]

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