Abstract
Hashimoto's encephalopathy (HE) is a rare neurological disorder with a heterogeneous group of neurological symptoms associated with high titres of anti-thyroid antibodies. Clinical manifestations may include encephalopathic features such as seizures, behavioural and psychiatric manifestations, movement disorders and coma. The objective of this presentation is to describe a patient with this rare and controversial clinical syndrome mimicking Creutzfeldt-Jakob disease, associated with a Hashimoto euthyroid thyroiditis and with a significant response to high dose intravenous prednisone. The responsiveness of this syndrome to steroids suggests that this disorder involves immune pathogenic mechanisms, as previous reviews reported.
MeSH terms
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Aged
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Aggression
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Anti-Inflammatory Agents / therapeutic use
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Arousal / physiology
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Autoantibodies / analysis
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Brain / pathology
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Brain Diseases / diagnosis*
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Brain Diseases / drug therapy*
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Brain Diseases / psychology
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Cerebral Cortex / pathology
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Confusion / etiology
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Confusion / psychology
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Creutzfeldt-Jakob Syndrome / diagnosis*
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Diagnosis, Differential
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Electroencephalography
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Encephalitis
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Hallucinations / etiology
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Hallucinations / psychology
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Hashimoto Disease / diagnosis*
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Hashimoto Disease / drug therapy*
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Hashimoto Disease / psychology
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Humans
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Magnetic Resonance Imaging
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Male
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Methylprednisolone / therapeutic use
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Neurologic Examination
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Psychomotor Agitation / etiology
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Thyroglobulin / immunology
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Tomography, X-Ray Computed
Substances
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Anti-Inflammatory Agents
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Autoantibodies
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Thyroglobulin
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Methylprednisolone