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Neuron. 2011 May 12;70(3):410-26. doi: 10.1016/j.neuron.2011.04.009.

The many faces of tau.

Author information

1
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.

Abstract

While the microtubule-binding capacity of the protein tau has been known for many years, new functions of tau in signaling and cytoskeletal organization have recently emerged. In this review, we highlight these functions and the potential roles of tau in neurodegenerative disease. We also discuss the therapeutic potential of drugs targeting various aspects of tau biology.

PMID:
21555069
PMCID:
PMC3319390
DOI:
10.1016/j.neuron.2011.04.009
[Indexed for MEDLINE]
Free PMC Article

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