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J Am Chem Soc. 2011 Jun 8;133(22):8474-7. doi: 10.1021/ja2026085. Epub 2011 May 17.

Rapid detection of a cocaine-binding aptamer using biological nanopores on a chip.

Author information

1
Bio Microsystems Project, Kanagawa Academy of Science and Technology (KAST), Kawasaki City, Japan.

Abstract

This paper describes a methodology for the rapid and highly selective detection of cocaine using a membrane protein channel combined with a DNA aptamer. The DNA aptamer recognizes the cocaine molecule with high selectivity. We successfully detected a low concentration of cocaine (300 ng/mL, the drug test cutoff limit) within 60 s using a biological nanopore embedded in a microchip.

PMID:
21553872
DOI:
10.1021/ja2026085
[Indexed for MEDLINE]

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