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Acta Pharmacol Sin. 2011 Jun;32(6):734-40. doi: 10.1038/aps.2011.47. Epub 2011 May 9.

Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury.

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1
Department of Psychology, Washington State University, Vancouver, WA, USA.

Abstract

Brain ischemia is a leading cause of death and long-term disabilities worldwide. Unfortunately, current treatment is limited to thrombolysis, which has limited success and a potential side effect of intracerebral hemorrhage. Searching for new cell injury mechanisms and therapeutic interventions has become a major challenge in the field. It has been recognized for many years that intracellular Ca(2+) overload in neurons is essential for neuronal injury associated with brain ischemia. However, the exact pathway(s) underlying the toxic Ca(2+) loading remained elusive. This review discusses the role of two Ca(2+)-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca(2+) toxicity associated with brain ischemia.

PMID:
21552295
PMCID:
PMC3395229
DOI:
10.1038/aps.2011.47
[Indexed for MEDLINE]
Free PMC Article
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