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Nat Methods. 2011 Jun;8(6):481-3. doi: 10.1038/nmeth.1604. Epub 2011 May 8.

Combining quantitative proteomics data processing workflows for greater sensitivity.

Author information

1
Department of Medical Protein Research, Vlaams Instituut voor Biotechnologie (VIB), Ghent, Belgium.

Abstract

We here describe a normalization method to combine quantitative proteomics data. By merging the output of two popular quantification software packages, we obtained a 20% increase (on average) in the number of quantified human proteins without suffering from a loss of quality. Our integrative workflow is freely available through our user-friendly, open-source Rover software (http://compomics-rover.googlecode.com/).

PMID:
21552256
DOI:
10.1038/nmeth.1604
[Indexed for MEDLINE]

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