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Optom Vis Sci. 2011 Aug;88(8):1005-9. doi: 10.1097/OPX.0b013e31821ddc6c.

Membrane array analysis of tear proteins in ocular cicatricial pemphigoid.

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1
Francis I. Proctor Research Foundation, University of California, San Francisco Medical School, San Francisco, California, USA.

Abstract

PURPOSE:

To explore non-invasive, protein-based, membrane array technology as a means to evaluate the global immune and angiogenic profile of tear proteins in patients with active ocular cicatricial pemphigoid (OCP).

METHODS:

Forty-three proteins consisting of cytokines, angiogenic/growth factors, and immunoinflammatory modulators were measured by membrane array in tear samples of four control patients and four OCP patients during active disease and after treatment.

RESULTS:

Signals for several distinct and consistent molecular entities were upregulated in all four active OCP tear samples relative to controls. In particular, interleukin-8 and matrix metalloproteinase-9 were elevated during active disease and decreased after systemic immunomodulatory therapy.

CONCLUSIONS:

Protein array analysis may provide a well-tolerated assay to monitor levels of inflammatory markers in the tears of OCP patients in response to therapy.

PMID:
21552176
PMCID:
PMC3667701
DOI:
10.1097/OPX.0b013e31821ddc6c
[Indexed for MEDLINE]
Free PMC Article
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