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Mol Cell Endocrinol. 2011 Jun 6;339(1-2):180-9. doi: 10.1016/j.mce.2011.04.014. Epub 2011 Apr 28.

Betaglycan: a multifunctional accessory.

Author information

1
Prince Henry's Institute, P.O. Box 5152, Clayton, Victoria 3168, Australia. maree.bilandzic@princehenrys.org

Abstract

Betaglycan is a co-receptor for the TGFβ superfamily, particularly important in establishing the potency of its ligands on their target cells. In recent years, new insights have been gained into the structure and function of betaglycan, expanding its role from that of a simple co-receptor to include additional ligand-dependent and ligand-independent roles. This review focuses on recent advances in the betaglycan field, with a particular emphasis on its newly discovered actions in mediating the trafficking of TGFβ superfamily receptors and as a determinant of the functional output of TGFβ superfamily signalling. In addition, this review encompasses a discussion of the emerging roles of the betaglycan/inhibin pathway in reproductive cancers and disease.

Republished in

PMID:
21550381
DOI:
10.1016/j.mce.2011.04.014
[Indexed for MEDLINE]

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