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Curr Biol. 2011 May 10;21(9):R305-7. doi: 10.1016/j.cub.2011.04.005.

Circadian rhythms: biological clocks work in phospho-time.

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1
Washington University Medical School, Saint Louis, MO 63110, USA.

Abstract

The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation.

PMID:
21549947
DOI:
10.1016/j.cub.2011.04.005
[Indexed for MEDLINE]
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