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Int J Antimicrob Agents. 2011 Jul;38(1):81-3. doi: 10.1016/j.ijantimicag.2011.03.007. Epub 2011 May 5.

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.

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Microbiology Laboratory, A9601, Seattle Children's Hospital, 4800 Sand Point Way, NE, Seattle, WA 98105, USA.


Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.

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