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Int J Antimicrob Agents. 2011 Jul;38(1):81-3. doi: 10.1016/j.ijantimicag.2011.03.007. Epub 2011 May 5.

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.

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1
Microbiology Laboratory, A9601, Seattle Children's Hospital, 4800 Sand Point Way, NE, Seattle, WA 98105, USA. xuan.qin@seattlechildrens.org

Abstract

Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)(LC) gene not previously described in S. aureus. The native plasmids carrying vga(A)(LC) were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.

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