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Cell Commun Signal. 2011 May 8;9:11. doi: 10.1186/1478-811X-9-11.

Mammalian Sirt1: insights on its biological functions.

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Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia -7003, Bangladesh.


Sirt1 (member of the sirtuin family) is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase that removes acetyl groups from various proteins. Sirt1 performs a wide variety of functions in biological systems. The current review focuses on the biological functions of Sirt1 in obesity-associated metabolic diseases, cancer, adipose tissue, aging, cellular senescence, cardiac aging and stress, prion-mediated neurodegeneration, inflammatory signaling in response to environmental stress, development and placental cell survival.

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