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Nat Rev Cancer. 2011 Apr;11(4):237-8. doi: 10.1038/nrc3036.

Of cancer and cave fish.

Author information

1
Departments of Radiology and Integrated Mathematical Oncology, Moffitt Cancer Center, Tampa, Florida 33612, USA. Robert.Gatenby@Moffitt.org

Abstract

We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context.

PMID:
21548400
PMCID:
PMC3971416
DOI:
10.1038/nrc3036
[Indexed for MEDLINE]
Free PMC Article

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