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Mol Endocrinol. 2011 Aug;25(8):1257-79. doi: 10.1210/me.2011-0099. Epub 2011 May 5.

Minireview: The roles of small RNA pathways in reproductive medicine.

Author information

1
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA. shannonh@bcm.edu

Abstract

The discovery of small noncoding RNA, including P-element-induced wimpy testis-interacting RNA, small interfering RNA, and microRNA, has energized research in reproductive medicine. In the two decades since the identification of small RNA, first in Caenorhabditis elegans and then in other animals, scientists in many disciplines have made significant progress in elucidating their biology. A powerful battery of tools, including knockout mice and small RNA mimics and antagonists, has facilitated investigation into the functional roles and therapeutic potential of these small RNA pathways. Current data indicate that small RNA play significant roles in normal development and physiology and pathological conditions of the reproductive tracts of females and males. Biologically plausible mRNA targets for these microRNA are aggressively being discovered. The next phase of research will focus on elucidating the clinical utility of small RNA-selective agonists and antagonists.

PMID:
21546411
PMCID:
PMC3146245
DOI:
10.1210/me.2011-0099
[Indexed for MEDLINE]
Free PMC Article

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