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Curr Opin Cell Biol. 2011 Oct;23(5):615-20. doi: 10.1016/j.ceb.2011.04.001. Epub 2011 May 3.

Endosomal signaling and cell migration.

Author information

1
Biocenter, Division of Cell Biology, Innsbruck Medical University, A6020 Innsbruck, Austria.

Abstract

Cell migration is a complex biological process that is under the tight control of diverse signaling events. While many of the involved signaling molecules diffuse rapidly within cells, it now seems that certain key regulators of cell migration prefer to travel on endosomes. In this review we will discuss the multiple roles of signaling endosomes in regulation of local migration stimuli, dynamics of focal adhesions, cell contractility and locomotion.

PMID:
21546233
PMCID:
PMC3188704
DOI:
10.1016/j.ceb.2011.04.001
[Indexed for MEDLINE]
Free PMC Article

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