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J Virol. 1990 Mar;64(3):1353-6.

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

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  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

Abstract

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

PMID:
2154613
PMCID:
PMC249255
[PubMed - indexed for MEDLINE]
Free PMC Article
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