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Biopolymers. 2011 Nov;95(11):733-45. doi: 10.1002/bip.21646. Epub 2011 May 4.

The effects of shear flow on protein structure and function.

Author information

1
Department of Chemical and Biomolecular Engineering, University of Melbourne, Parkville, VIC 3010, Australia.

Abstract

Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed.

PMID:
21544798
DOI:
10.1002/bip.21646
[Indexed for MEDLINE]

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