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Proc Am Thorac Soc. 2011 May;8(2):149-53. doi: 10.1513/pats.201101-003MS.

Genetics of complex airway disease.

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1
National Heart and Lung Institute, London SW3 6LY, UK. w.cookson@imperial.ac.uk

Abstract

The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.

PMID:
21543792
PMCID:
PMC3131831
DOI:
10.1513/pats.201101-003MS
[Indexed for MEDLINE]
Free PMC Article
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