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Arch Dis Child. 2012 Jun;97(6):514-6. doi: 10.1136/adc.2010.202069. Epub 2011 May 4.

Interferon-γ release assay for the diagnosis of tuberculosis in children.

Author information

1
Paediatric Department, La Paz Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain. amendezes@yahoo.es

Abstract

AIMS:

To compare the QuantiFERON-TB GOLD In Tube test (QTF) and the tuberculin skin test (TST) in children.

METHODS:

A prospective study was carried out in nine hospitals in Madrid, Spain. TST and QTF were performed in immigrants, tuberculosis (TB) contacts and patients with TB disease (TBD).

RESULTS:

459 children were included. Disagreement between the tests was more frequently observed among latent tuberculosis infection (LTBI) cases (54%; 38/70) than in non-infected or TBD cases (0.8%; 3/369) (p<0.01). There were more BCG-vaccinated children among LTBI cases with negative QTF (76%) than among LTBI cases with positive QTF (40%) (p<0.001). Agreement between tests in BCG-vaccinated children was lower than in non-vaccinated cases (p<0.05). Tests in TB exposed patients showed better agreement than in non-exposed children (p<0.05).

CONCLUSIONS:

Agreement of both tests was excellent in TBD cases, non-vaccinated children and non-infected patients. A significant number of QTF negative results were observed among LTBI cases, especially in BCG-vaccinated children. Agreement was better in exposed children.

PMID:
21543457
DOI:
10.1136/adc.2010.202069
[Indexed for MEDLINE]

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