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Epilepsia. 2011 May;52 Suppl 3:33-9. doi: 10.1111/j.1528-1167.2011.03034.x.

Molecular cascades that mediate the influence of inflammation on epilepsy.

Author information

1
Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel. alonf@bgu.ac.il

Abstract

Experimental evidence strongly indicates a significant role for inflammatory and immune mediators in initiation of seizures and epileptogenesis. Here we will summarize data supporting the involvement of IL-1β, TNF-α and toll-like receptor 4 in seizure generation and the process of epileptogenesis. The physiological homeostasis and control over brain immune response depends on the integrity of the blood-brain barrier, transforming growth factor (TGF)-β signaling and leukocyte migration. To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research.

PMID:
21542844
PMCID:
PMC3638118
DOI:
10.1111/j.1528-1167.2011.03034.x
[Indexed for MEDLINE]
Free PMC Article

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