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Int J Oncol. 1996 Oct;9(4):693-9.

Diagnostic evaluation of cancer antigens RAK .1. Cervical and ovarian cancer.

Author information

1
UNIV NEBRASKA,EPPLEY CANC CTR,DEPT OBSTET & GYNECOL,OMAHA,NE. UNIV NEBRASKA,EPPLEY CANC CTR,DEPT BIOCHEM & MOL BIOL,OMAHA,NE. UNIV NEBRASKA,EPPLEY CANC CTR,EPPLEY CANC INST,OMAHA,NE. UNIV POSNAN,GREAT POLAND CANC CTR,SCH MED SCI,DEPT CANC IMMUNOL,POZNAN,POLAND. K MARCINKOWSKI UNIV,SCH MED,DEPT ONCOL,POZNAN,POLAND.

Abstract

Cancer antigens RAK-p120, p42, and p25, which exhibit biological, immunological and molecular similarity to the proteins expressed by Human Immunodeficiency Virus 1 (HIV-1), were found in 47 of 47 tested cases of serous adenocarcinoma of the ovary, and 45 of 45 tested cases of squamous carcinoma of the cervix. Normal ovary and cervix did not express antigens RAK. High molecular weight protein (RAK-p160) was detected in the blood of over 61% of ovarian and 72% of cervical cancer patients, and in 14.3% of healthy women with family history of breast and/or gynecological cancer. Antigens RAK might represent new diagnostic markers.

PMID:
21541570
DOI:
10.3892/ijo.9.4.693

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