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Int J Mol Sci. 2011 Jan 31;12(2):1009-29. doi: 10.3390/ijms12021009.

Role of versican, hyaluronan and CD44 in ovarian cancer metastasis.

Author information

1
Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia; E-Mails: miranda.ween@adelaide.edu.au (M.P.W.); martin.oehler@adelaide.edu.au (M.K.O.).

Abstract

There is increasing evidence to suggest that extracellular matrix (ECM) components play an active role in tumor progression and are an important determinant for the growth and progression of solid tumors. Tumor cells interfere with the normal programming of ECM biosynthesis and can extensively modify the structure and composition of the matrix. In ovarian cancer alterations in the extracellular environment are critical for tumor initiation and progression and intra-peritoneal dissemination. ECM molecules including versican and hyaluronan (HA) which interacts with the HA receptor, CD44, have been shown to play critical roles in ovarian cancer metastasis. This review focuses on versican, HA, and CD44 and their potential as therapeutic targets for ovarian cancer.

KEYWORDS:

CD44; adhesion; extracellular matrix; hyaluronan; metastasis; versican

PMID:
21541039
PMCID:
PMC3083686
DOI:
10.3390/ijms12021009
[Indexed for MEDLINE]
Free PMC Article
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