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EMBO J. 2011 May 4;30(9):1673-5. doi: 10.1038/emboj.2011.107.

Unlocking SOAR releases STIM.

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1
Department of Pharmacology, Yonsei University, Seoul, Korea.

Abstract

A crucial component of the receptor-evoked Ca(2+) signal is Ca(2+) influx mediated by the store-operated Ca(2+) channels (SOCs). The molecular makeup of one SOC is the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the pore-forming Orai1. Ca(2+) release from the ER leads to co-clustering of STIM1 and Orai1 to activate Orai1. The short STIM1 SOAR/CAD domain (STIM1 Orai1-activating region/CRAC-activating domain), which has two coiledcoil (C–C) domains, interacts with the Orai1 C terminus C–C domain to activate the channel. How the function of SOAR is regulated is not known. Korzeniowski et al (2010) and Muik et al (2011; this issue) now identified an autoinhibitory domain in STIM1 that occludes SOAR. Release of SOAR involves a conformational transition that is aided by the Orai1 C–C domain.

PMID:
21540881
PMCID:
PMC3101985
DOI:
10.1038/emboj.2011.107
[Indexed for MEDLINE]
Free PMC Article
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