Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Cell Biol. 2011 May;13(5):523-5. doi: 10.1038/ncb0511-523.

iPS cells forgive but do not forget.

Abstract

Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

PMID:
21540851
DOI:
10.1038/ncb0511-523
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center