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Nat Cell Biol. 2011 May;13(5):506-12. doi: 10.1038/ncb0511-506.

Emerging models and paradigms for stem cell ageing.

Author information

1
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Abstract

Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.

PMID:
21540846
PMCID:
PMC3257978
DOI:
10.1038/ncb0511-506
[Indexed for MEDLINE]
Free PMC Article

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