Format

Send to

Choose Destination
See comment in PubMed Commons below
Channels (Austin). 2011 May-Jun;5(3):198-200. Epub 2011 May 1.

Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK.

Author information

1
Department of Biological Sciences, University of Calgary, Institute for Biocomplexity and Informatics, Calgary, AB, Canada.

Abstract

Studies of the non-selective NaK channel as a model system provided detailed structural and functional insights into different factors that modulate selective ion conductance. The combination of structural and functional studies of WT- and mutant forms of NaK channel show that apparent conservation of the multiple binding sites in the canonical selectivity filter of K-channel is essential component of the observed robust Na (+) discrimination.

PMID:
21540644
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center