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Biophys J. 2011 May 4;100(9):2077-83. doi: 10.1016/j.bpj.2011.03.020.

Impact of heparan sulfate chains and sulfur-mediated bonds on the mechanical properties of bovine lens capsule.

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CSIRO Materials Science and Engineering, Clayton, Australia.

Erratum in

  • Biophys J. 2011 Jun 8;100(11):2852. Dyksterhuis, L D [corrected to Dyksterhuis, L B].


We assessed the importance of glycosaminoglycans and sulfur-mediated bonds for the mechanical properties of lens capsules by comparing the stress-strain responses from control and treated pairs of bovine source. No significant change in mechanical properties was observed upon reduction of disulfide bonds. However, removal of glycosaminoglycan chains resulted in a significantly stiffer lens capsule, whereas high concentrations of reducing agent, which is expected to reduce the recently reported sulfilimine bond of collagen IV, resulted in a significantly less stiff lens capsule. A comparison of the diffraction patterns of the control and strongly reduced lens capsules indicated structural rearrangements on a nanometer scale.

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