Format

Send to

Choose Destination
See comment in PubMed Commons below
Stem Cell Res Ther. 2011 Apr 15;2(2):17. doi: 10.1186/scrt58.

Neural tissue engineering using embryonic and induced pluripotent stem cells.

Author information

1
Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, British Columbia, V8W 3P6 Canada. willerth@uvic.ca

Abstract

With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.

PMID:
21539726
PMCID:
PMC3226288
DOI:
10.1186/scrt58
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center