Format

Send to

Choose Destination
Phytother Res. 2011 Nov;25(11):1732-5. doi: 10.1002/ptr.3514. Epub 2011 Apr 28.

Icariin induces the expression of toll-like receptor 9 in ana-1 murine macrophages.

Author information

1
Guangxi Botanic Garden of Medicinal Plants, No. 189, Changgang Road, Nanning 530023, PR China. liboshi1963@vip.163.com

Abstract

Icariin is the major pharmacologically active compound of Herba epimedii which has been used as a tonic, aphrodisiac and an antirheumatic in traditional Chinese medicine. This study analysed the effect of icariin on the expression of Toll-like receptor 9 (TLR9) which plays an important role in regulation of the innate immune response. Stimulation of Ana-1 murine macrophages with icariin induced a significant dose-dependent expression of TLR9, and its mRNA expression which increased from 3 h post-treatment was approximately five-fold that of DMSO-treated cells. Several molecules, such as myeloid differentiation factor 88, tumor necrosis factor-α and interleukin 6, which are involved in the TLR9 downstream signaling pathway, were also significantly up-regulated in response to icariin stimulation. Our findings demonstrated that icariin is able to induce the expression of TLR9.

PMID:
21538629
DOI:
10.1002/ptr.3514
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center