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Dtsch Med Wochenschr. 2011 May;136(18):939-43. doi: 10.1055/s-0031-1275829. Epub 2011 May 2.

[Adherence to the H1N1 vaccination recommendation in patients with Crohn's disease or ulcerative colitis].

[Article in German]



In September 2009, the German "Standing Committee for Vaccination" (STIKO) recommended the H1N1 influenza vaccination to all patients with chronic diseases. We investigated the adherence to this recommendation in patients with the inflammatory bowel diseases (IBD) Crohn's disease or ulcerative colitis. Special attention was paid to arguments for vaccination refusal.


In an explorative multicenter study we asked adult patients to answer a questionnaire about their participation in the H1N1 vaccination campaign, their arguments for and against this vaccination and disease specific parameters.


Out of 1389 participating patients, 226 (16 %) received the H1N1 vaccination. Among patients who were vaccinated against the seasonal flu as well as patients who were treated with anti-TNF-treatment and members of the German Crohn's and Colitis Association, the participation rates were significantly higher (32 %, 26 %, 25 %, respectively). The main argument against the H1N1 vaccination was fear of side effects (59 %). However, 77 % of all vaccinated patients judged the vaccine as very well tolerated. The non-adherence to general vaccination recommendations against tetanus and seasonal flu was also high (25 % and 66 %, respectively).


Only a minority of patients with Crohn's disease or ulcerative colitis had adhered to the official recommendation concerning vaccination against H1N1. In order to reach higher acceptance, further vaccination campaigns must focus on the safety of the recommended vaccine.

[Indexed for MEDLINE]

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