The Helicobacter pylori Ferric Uptake Regulator (Fur) is essential for growth under sodium chloride stress

J Microbiol. 2011 Apr;49(2):294-8. doi: 10.1007/s12275-011-0396-7. Epub 2011 May 3.

Abstract

Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gene Expression Profiling
  • Gene Knockout Techniques
  • Helicobacter pylori / drug effects*
  • Helicobacter pylori / genetics
  • Helicobacter pylori / growth & development*
  • Osmotic Pressure*
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*
  • Sodium Chloride / metabolism*

Substances

  • Bacterial Proteins
  • Repressor Proteins
  • ferric uptake regulating proteins, bacterial
  • Sodium Chloride