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Cell Mol Neurobiol. 2011 Aug;31(6):939-48. doi: 10.1007/s10571-011-9691-4. Epub 2011 May 3.

Aβ oligomer-induced synapse degeneration in Alzheimer's disease.

Author information

1
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA. k-wilcox@northwestern.edu

Abstract

Aβ oligomers cause a collection of molecular events associated with memory loss in Alzheimer's disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of Aβ oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity-especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer's disease.

PMID:
21538118
PMCID:
PMC3146579
DOI:
10.1007/s10571-011-9691-4
[Indexed for MEDLINE]
Free PMC Article

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