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World J Biol Chem. 2010 Nov 26;1(11):327-37. doi: 10.4331/wjbc.v1.i11.327.

Role of sphingosine 1-phosphate in anti-atherogenic actions of high-density lipoprotein.

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Koichi Sato, Fumikazu Okajima, Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan.


The reverse cholesterol transport mediated by high-density lipoprotein (HDL) is an important mechanism for maintaining body cholesterol, and hence, the crucial anti-atherogenic action of the lipoprotein. Recent studies, however, have shown that HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of cholesterol metabolism. The present review provides an overview of the roles of sphingosine 1-phosphate (S1P)/S1P receptor and apolipoprotein A-I/scavenger receptor class B type I systems in the anti-atherogenic HDL actions. In addition, the physiological significance of the existence of S1P in the HDL particles is discussed.


Anti-atherogenic actions; High-density lipoprotein; Scavenger receptor class B type I; Sphingosine 1-phosphate

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