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Curr Opin Biotechnol. 2011 Oct;22(5):648-54. doi: 10.1016/j.copbio.2011.04.007. Epub 2011 Apr 30.

More than a feeling: discovering, understanding, and influencing mechanosensing pathways.

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1
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

The ability of cells to extract biophysical information from their extracellular environment and convert it to biochemical signals is known as mechanotransduction. Here we detail three passive, 'inside-out' mechanotransduction mechanisms with an emphasis on the mechanosensing pathways involved in creating these signal: Rho/ROCK, stretch-activated channels, and 'Molecular Strain Gauges.' We also examine how molecular tools have been used to perturb these pathways to better understand their interconnectivity. However, perturbing pathways may have unintended confounding effects, which must also be addressed. By discovering and understanding mechanosensitive pathways, the ability to influence them for clinical applications increases.

PMID:
21536426
PMCID:
PMC3150613
DOI:
10.1016/j.copbio.2011.04.007
[Indexed for MEDLINE]
Free PMC Article
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