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Int J Oncol. 1997 Mar;10(3):503-7.

Cyclooxygenase-2 gene expression in human breast cancer.

Author information

1
OHIO STATE UNIV,DEPT MED MICROBIOL & IMMUNOL,COLL MED,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,DEPT PATHOL,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,SCH PUBL HLTH,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL MED,CTR COMPREHENS CANC,COLUMBUS,OH 43210.

Abstract

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to tumor cells. These results indicate that COX-2 gene expression may be useful as a molecular biomarker for human breast tumors and may also predict sensitivity to treatment with nonsteroidal anti-inflammatory drugs.

PMID:
21533404
DOI:
10.3892/ijo.10.3.503

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