Format

Send to

Choose Destination
Int J Oncol. 1997 Feb;10(2):349-53.

BRCA1-p53 relationship in hereditary breast cancer.

Author information

1
INST J PAOLI I CALMETTES,LAB TUMOR BIOL,F-13009 MARSEILLE,FRANCE. INST CURIE,UNIT GENET ONCOL,PARIS,FRANCE. INST GUSTAVE ROUSSY,DEPT BIOL CLIN,F-94805 VILLEJUIF,FRANCE. CTR OSCAR LAMBRET,LAB HUMAN MOL ONCOL,F-59020 LILLE,FRANCE. INST GUSTAVE ROUSSY,DEPT PATHOL,VILLEJUIF,FRANCE. INSERM U119,MARSEILLE,FRANCE. INST J PAOLI I CALMETTES,DEPT PATHOL,F-13009 MARSEILLE,FRANCE.

Abstract

BRCA1, a major gene predisposing to breast and ovarian cancers, encodes a ring finger-containing protein. Its function is still unknown. Recently, the existence of a new structural domain called BRCT was postulated. This domain has some similarity with the 53BP1 human protein involved in p53 binding process. To test for a possible relationship between BRCA1 and p53, we compared p53 expression by immunohistochemical analysis in 29 BRCA1-associated breast cancers from 19 families, and in 200 consecutive sporadic breast cancers. We observed a prevalence of tumors with p53 positive staining in the BRCA1 population (p=0.003). In addition, p53 expression was affected by the site of the germ line mutation in the BRCA1 gene. p53 staining was found more consistently in tumors associated with mutations that lead to a truncation of BRCA1 in the ring finger region (p=0.0048). These results favor the hypothesis of a cooperation between BRCA1 and p53. Further experiments are needed to explore the full bilogical relevance of this phenomenon.

PMID:
21533383
DOI:
10.3892/ijo.10.2.349

Supplemental Content

Full text links

Icon for Spandidos Publications
Loading ...
Support Center