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J Med Chem. 1990 Jan;33(1):61-70.

Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.

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1
Hoechst AG, Frankfurt (Main), West Germany.

Abstract

A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)- enoates (-heptanoates) 1 and 2 have been prepared and tested for inhibiti 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The most potent compounds exceeded mevinolin's activity in vitro and in vivo.

PMID:
2153213
DOI:
10.1021/jm00163a011
[Indexed for MEDLINE]

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