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Gastroenterology. 2011 May;140(6):1838-46. doi: 10.1053/j.gastro.2011.02.014.

Future therapeutic approaches for inflammatory bowel diseases.

Author information

1
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic and genetic biomarkers to personalize medicine. We attempt to reconcile past therapeutic successes and failures to improve future approaches. Some of our ideas might be provocative, but we hope that the examples we provide will stimulate discussion about what will advance the field of IBD therapy.

PMID:
21530750
PMCID:
PMC5076881
DOI:
10.1053/j.gastro.2011.02.014
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors disclose the following: Scott E. Plevy: speaker at CME Symposia partially or completely funded: Abbott Immunology; Centocor, Inc; UCB. Advisory committees: Abbott Immunology, Centocor, Inc; Elan Pharmaceuticals; Eli Lilly; Genentech, Inc; GlaxoSmithKline; Merck; Novartis; Prometheus Laboratories; Takeda Pharmaceuticals; UCB. Stephan R. Targan: cofounder and share holder: Prometheus Laboratories.

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